Seronegative autoimmune hepatitis in childhood

Figure 1 B cell role in the pathogenesis of autoimmune hepatitis. T cells allow B cells to switch to antibody-producing plasma cells. Autoreactive B cells release autoantibody and cytokine/chemokines. B cells continue to contribute to inflammation by presenting antigen to T cells and cause autoantibody-mediated activation of macrophage/dendritic cells, while suppressing the anti-inflammatory effects of Treg and B cells. Treg: Regulatory T cell.