Food allergy in children—the current status and the way forward

Table 1 World Allergy Organization systemic allergic reaction grading system

System	Grade 1	Grade 2	Grade 3	Grade 4	Grade 5
	One organ system involved (cutaneous, respiratory, ocular or others)	Two organ systems involved, or lower respiratory tract involvement, gastrointestinal involvement, or uterine cramping
Cutaneous	Generalised pruritus, urticaria, flushinor a sensation of heat or warmth, or angioedema not involving laryngeal, tongue, or uvular tissues. Localised hives or angioedema alone are not considered anaphylaxis
Respiratory	Upper respiratory tract symptoms: sneezing, rhinorrhea, nasal pruritus and nasal congestion, throat clearing, itchy throat, and coughing	Lower respiratory tract symptoms: wheezing, shortness of breath. And a drop of 40% in the forced expiratory volume in one second (FEV1) and which responds to bronchodilators	Symptoms of laryngeal, uvular, or tongue tissue oedema. With or without stridor. Or FEV1 drops by 40% with no response to bronchodilators	Respiratory failure
Cardiovascular				Hypotension
Gastrointestinal		Abdominal cramping, vomiting or diarrhoea
Conjunctival	Conjunctival erythema, pruritus, or tearing
Other	Nausea, metallic taste, or headache	Uterine cramping			Death