Advances in pediatric non-alcoholic fatty liver disease: From genetics to lipidomics

Table 1 Main genes and changes in methylation found in human epigenomics studies in non-alcoholic fatty liver disease

Gene	Changes	Methods	Ref.
FGFR2	Hypomethylation	Bisulfite pyrosequencing and liver biopsy	Zhang et al[112]
MAT1A	Hypomethylation	Bisulfite pyrosequencing and liver biopsy	Zhang et al[112]
CASP1	Hypomethylation	Bisulfite pyrosequencing and liver biopsy	Zhang et al[108]
MTND6	Hypomethylation	Methylation-specific PCR and liver biopsy	Pirola et al[109]
PARVB	Hypomethylation	Targeted-bisulfite sequencing and liver biopsy	Kitamoto et al[111]
PNPLA3	Hypomethylation	Targeted-bisulfite sequencing and liver biopsy	Kitamoto et al[111]
PPARα	Hypomethylation	Bisulfite pyrosequencing and liver biopsy	Zeybel et al[112]
TGFβ1	Hypomethylation	Bisulfite pyrosequencing and liver biopsy	Zeybel et al[112]
Collagen 1A1	Hypomethylation	Bisulfite pyrosequencing and liver biopsy	Zeybel et al[112]
PDGFα	Hypomethylation	Bisulfite pyrosequencing and liver biopsy	Zeybel et al[112]
PPARGC1A	Hypomethylation	Methylation-specific PCR and liver biopsy	Sookoian et al[113]
cg08309687 (LINC00649)	Hypomethylation	Illumina BeadChip for array analyses	Ma et al[114]
NPC1L1	Methylation	Illumina human methylation 450 Beadchip and liver biopsy	Mwinyi et al[116]
STARD	Methylation	Illumina human methylation 450 Beadchip and liver biopsy	Mwinyi et al[116]
GRHL	Methylation	Illumina human methylation 450 Beadchip and liver biopsy	Mwinyi et al[116]

PCR: Polymerase chain reaction.