Sickle cell nephropathy: A review of novel biomarkers and their potential roles in early detection of renal involvement

Table 1 Estimated glomerular filtration rate formulas employed in sickle cell nephropathy

Formula	Equation
CKD-EPI (Cr)	F with Cr ≤ 62 μmol/L (≤ 0.7 mg/dL): 144 × (creatinine/0.7) - 0.329 × 0.993 age (× 1.159 if Black); F with Cr > 62 μmol/L (> 0.7 mg/dL): 144 × (creatinine/0.7) - 1.209 × 0.993 age (× 1.159 if Black)
	M with Cr ≤ 80 μmol/L (≤ 0.9 mg/dL): 141 × (creatinine/0.9) - 0.411 × 0.993 age (× 1.159 if Black); M with Cr > 80 μmol/L (> 0.9 mg/dL): 141 × (creatinine/0.9) - 1.209 × 0.993 age (× 1.159 if Black)
MDRD	175 × creatinine - 1.154 × age - 0.203 × 0.742 (if female)
Schwartz	0.413 × [height (cm)/creatinine]
CKD-EPI (Cystatin C)	Cystatin C ≤ 0.8 mg/L: 133 × (cystatin C/0.8) - 0.499 × 0.996 age (× 0.932 if female); Cystatin C > 0.8 mg/L: 133 × (cystatin C/0.8) - 1.328 × 0.996 age (× 0.932 if female)

CKD-EPI: Chronic kidney disease epidemiology; Cr: Creatinine; F: Female, M: Male; MDRD: Modification of diet in renal disease.