Prevalence of pulmonary hypertension among children with Down syndrome: A systematic review and meta-analysis

Table 1 Characteristics of studies included in the meta-analysis

Ref.	Year	Timing of data collection	Study design	Country	Population size	Cases with PH	Prevalence of PH
De Rubens et al[48]	2003	Retrospective	Observational	Mexico	275	41	14.90909
Shah et al[33]	2004	Retrospective	Observational	Canada	175	24	13.71429
Cua et al[35]	2007	Retrospective	Observational	USA	58	7	12.06897
Weijerman et al[40]	2010	Prospective	Cohort	Netherlands	820	25	3.04878
Banjar et al[41]	2012	Retrospective	Observational	Saudi Arabia	59	44	74.57
Mourato et al[42]	2013	Retrospective	Cross-sectional	Brazil	138	42	30.43478
Sharma et al[43]	2013	Prospective	Observational	India	35	18	51.42857
Shrestha et al[36]	2013	Prospective	Observational	Nepal	50	21	42
Espinola-Zavaleta et al[44]	2015	Prospective	Observational	Mexico city	127	102	80.31496
Bermudez et al[34]	2015	Retrospective	Observational	Brazil	1207	57	4.722452
Zonouzi et al[45]	2015	Prospective	Cross-sectional	Iran	110	23	20.90909
Joffre et al[6]	2016	Retrospective	Observational	France	66	19	28.78788
Okeniyi et al[37]	2017	Prospective	Observational	Nigeria	70	14	20
Bush et al[38]	2018	Retrospective	Cohort	USA	1252	346	27.63578
Martin et al[39]	2018	Retrospective	Cohort	Ireland	121	41	33.8843
Zahari et al[46]	2019	Retrospective	Cohort	Malaysia	754	160	21.22016
Alsuwayfee et al[47]	2020	Prospective	Cross-sectional	Iraq	76	23	30.26

PH: Pulmonary hypertension.