Oral graft vs host disease: An immune system disorder in hematopoietic cell transplantation

Table 3 Shulman et al[12] chronic graft-vs-host disease histologic classification of oral mucosa and salivary glands, according to National Institutes of Health Consensus

Epithelium	Epithelial thickness (normal, atrophic, hyperkeratosis and acanthosis), presence of vacuolization, apoptosis, spongiosis, atypical keratinocytes, exocytosis of lymphocytes, presence of other inflammatory cells and thickening of basal lamina
Lamina propria	Predominant cell type in the inflammatory infiltrate and their distribution in relation to the salivary duct and epithelium
Salivary glands	Lymphocytes within the duct, periductal mixed infiltrate, presence of lymphocytes within the acini, apoptosis in the ducts and acini, periductal fibrosis, acinar cell degeneration, interstitial fibrosis, duct ectasia and loss of polarity of epithelial cells of the duct