Oral graft vs host disease: An immune system disorder in hematopoietic cell transplantation

Table 2 Minimal criteria for diagnosis of oral chronic graft vs host disease and categories

Category	Definition
Not GVHD	No evidence for GVHD
Possible GVHD	Evidence of GVHD but other possible explanations (e.g., Clinical features that suggest or favor a drug reaction)
Consistent with GVHD	Clear evidence of GVHD with mitigating factors (e.g., Unequivocal evidence of CMV yet abundant apoptotic epithelial changes that are not associated with CMV- infected cells by immunostaining)
GVHD	Unequivocal evidence of GVHD and no further comment necessary (e.g., Inflammation may be minimal despite extensive destruction of the targeted epithelia)

Adapt from Shulman et al[12]. GVHD: Graft vs host disease: CMV: Cytomegalovirus.