Non-surgical periodontal therapy: An update on current evidence

Table 4 Summary of systematic reviews on host modulation therapy

Systematic review	No. of studies	Treatment modalities	Tested clinical parameters	Conclusion
Reddy et al[89]	7 (SDD), 10 (NSAIDs), 3 (BPs)	Adjuntive efficacy of anti-proteinases, anti-inflammatory agents, and anti-resorptive	Bone changes, CAL, PPD, plaque index, gingivitis	Use of SDD+ SRP‡ is statistically more effective than SRP alone in reducing PPD and achieving CAL gain Insufficient data for NSAIDs and BPs may have potential adjunctive role in periodontal therapy
Preshaw et al[92]	2	SDD + SRP vs SRP + placebo	CAL, PPD	Adjunctive SDD enhances therapeutic outcomes compared with SRP alone, resulting in clinical benefit in both smokers and non-smokers with chronic periodontitis
Sgolastra et al[91]	3	SDD + SRP vs SRP + placebo	CAL, PPD, Plaque Index, Gingival Index, and gingival crevicular fluid levels	Supports long-term effectiveness of adjunctive SDD therapy
Moreno Villagrana et al[90]	9	SDD + SRP vs SRP + placebo	CAL, PPD	Statistically significant results in patients with aggressive or chronic periodontitis under periodontal treatment

SDD: Subantimicrobial dose doxycycline; NSAID: Non steroidal antiinflammatory drug; BP: Bisphosphonates; CAL: Clinical attachment level; PPD: Probing pocket depth; SRP: Scaling and root planing.