Phenotyping emphysema and airways disease: Clinical value of quantitative radiological techniques

Table 7 Summary of studies comparing magnetic resonance imaging and computed tomography in chronic obstructive pulmonary disease

Ref.	Year	Pt No.	Variables	Results
Ley et al[96]	2004	13	ADC and EI vs FEV1	ADC vs FEV1, R = 0.7 EI vs FEV1, R = 0.5 MLD vs FEV1, R = 0.4
Ohno et al[93]	2008	71	O2 enhanced MRI (mean wash in time and relative enhancement ratio), CT defined lung volumes vs lung function	Mean wash in time vs FEV1, r = -0.74 Relative Enhancement Ratio vs KCO, r = 0.66 CT lung volume vs FEV1, r = 0.61 CT lung volume vs KCO, r = 0.56
Van Beek et al[98]	2009	94	ADC and MLD vs FEV1/FVC and DLCO	ADC vs Fev1/fvc, r = 0.5 MLD vs Fev1/fvc, r = 0.52 ADC vs DLCO, r = 0.59 MLD vs DLCO, r = 0.29
Diaz et al[38]	2009	27	ADC and EI vs FEV1 and DLCO	ADC vs FEV1, r = 0.67 EI vs FEV1, r = 0.55 ADC vs DLCO, r = -0.82 Perc15 vs DLCO, r = 0.6
Quirk et al[114]	2011	30	Hyperpolarised He vs CT density in at risk smokers	Lung morphometry vs %LAA 950: Significant difference seen in those still smoke, not on CT
Xia et al[101]	2014	55	+ve rate of Perfusion defects vs CT changes	Early COPD: MRI detected 8/8, vs CT 3/8 P = 0.003 Mod. COPD: MRI detected 9/9, vs CT 7/9 P = 0.47
Hueper et al[95]	2015	144	DCE-MRI vs CT density	PMBF vs %LAA 950: Evidence of non-linearity, P = 0.015

ADC: Apparent diffusion co-efficient; EI: Emphysema index; FEV1: Forced expiratory volume in 1 second; MLD: Mean lung density; MRI: Magnetic resonance imaging; DLCO: Transfer factor for carbon monoxide; KCO: Transfer co-efficient; COPD: Chronic obstructive pulmonary disease; DCE-MRI: Dynamic contrast enhanced-magnetic resonance imaging.