Copyright
©The Author(s) 2017.
World J Respirol. Mar 28, 2017; 7(1): 1-16
Published online Mar 28, 2017. doi: 10.5320/wjr.v7.i1.1
Published online Mar 28, 2017. doi: 10.5320/wjr.v7.i1.1
Table 1 Summary of studies dividing patients as HRCT defined phenotypes and their significant differences clinical and physiological (P < 0.05)
Ref. | HRCT defined phenotypes | Variables studied | Significant variable difference |
Kitaguchi et al[8], 2006 | A: Little or none of either emphysema or BWT E: Emphysema but no BWT M: Emphysema and BWT | Gas exchange Gas transfer Lung function Response to beta-agonist Response to treatment with ICS Sputum cell differentiation | A: ↑ BMI ↑DLCO ↓ hyperinflation ↑ reversibility ↑response to ICS ↑ % of sputum eosinophils E: No response to ICS M: ↑ response to ICS ↑ % of sputum eosinophils |
Fujimoto et al[9], 2006 | A: Little or none of either emphysema or BWT E: Emphysema but no BWT M: Emphysema and BWT | Exacerbation rates Gas exchange Gas transfer Hospital admissions Lung function Response to beta-agonist Symptoms | M: ↑ volume of sputum, exacerbation rate and admission to hospital |
Pistolesi et al[10], 2008 | From derivation set, created new validation set Group A and B | CT parameters Gas exchange Gas transfer Lung function | A: ↓ FEV1, ↑ TLC ↓ DLCO. ↑ pixel index (threshold -950HU) B: ↑ BMI purulent sputum worse bronchial wall thickening |
Han et al[7], 2011 | Emphysema predominant or Airway predominant | BWT Exacerbation rates lung function % emphysema | Emphysema Predominant (> 35% -950HU): ↓ FEV1 and 6MWD ↑ SGRQ and MRC grade For every 5% ↑ in emphysema, 1.18 fold ↑ exacerbation frequency Airways predominant: For 1 mm ↑ in segmental BWT 1.84 fold ↑ in exacerbation frequency |
Subramanian et al[3], 2016 | Emphysema dominant, airways disease dominant, mixed pathology and mild disease | Blood parameters CT parameters Gas exchange Gas transfer Lung volumes Spirometry | Compared with airway disease dominant group, emphysema dominant group had ↑ lung volumes, ↓ gas transfer ↓ pO2 + pCO2↓BMI ↑Hb No difference between age, and smoking history between the groups |
Da Silva et al[2], 2016 | Emphysema or airways disease | Clinical + functional evaluation HRCT | Emphysema group: ↑ airflow obstruction ↓ BMI ↓ 6MWD |
- Citation: Crossley D, Turner A, Subramanian D. Phenotyping emphysema and airways disease: Clinical value of quantitative radiological techniques. World J Respirol 2017; 7(1): 1-16
- URL: https://www.wjgnet.com/2218-6255/full/v7/i1/1.htm
- DOI: https://dx.doi.org/10.5320/wjr.v7.i1.1