Post splenectomy related pulmonary hypertension

Table 3 List of splenectomy and pulmonary hypertension studies

Ref.	Patient cohort (n)	Study design	No. of patients with splenectomy	Method of PH diagnosis	Comment
Hoeper et al[8]	Unexplained PHTN (61)	Retrospective	7	RHC	3 patients had splenectomy for hereditary spherocytosis and trauma, one patient with ITP
Jaïs et al[11]	CTEPH (257)	Retrospective	22 (8.6%)	RHC	15 patients had splenectomy after trauma, 4 with hemolytic disorder
Jaïs et al[11]	Idiopathic PHTN (276)	Retrospective	7 (2.5%)	RHC	Lower prevalence of splenectomy in idiopathic PHTN compared to prior study
Phrommintikul et al[38]	PHTN in Thalassemia with Hb < 10 g/dL (29)	Retrospective	29 (75.8%)	TTE	Increased prevalence of PHTN with higher nucleated red cells, platelets and transfusion requirement in splenectomised patients than those with intact spleen
Elstein et al[16]	Gaucher’s disease (134), 9 patients had PH	Retrospective	6	TTE	All patients with PHTN had enzyme replacement therapy
Stewart et al[15]	Hereditary stomatocytosis after splenectomy (9)	Retrospective	9	2 RHC	3 patients developed CTEPH, one portal hypertension
				1 on autopsy
Palkar et al[63]	PHTN after splenectomy (9)	Retrospective	9	RHC	4 patients belonged to group 1, two to group 4 and one each in groups 2, 3 and 5

RHC: Right heart catheterization; TTE: Transthoracic echocardiography; ITP: Immune thrombocytopenic purpura; PHTN: Pulmonary hypertension.