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Copyright ©The Author(s) 2015.
World J Respirol. Jul 28, 2015; 5(2): 152-159
Published online Jul 28, 2015. doi: 10.5320/wjr.v5.i2.152
Table 3 Implication of hydrogen sulfide in the pathophysiology in human airway diseases - its use as a biomarker
Disease
COPDHigher serum H2S level in patients with COPD compared with healthy subjects[16]
Acute exacerbation of COPD decreases serum H2S level compared to patients with stable COPD[16,42]
Higher sputum H2S levels in patients with acute exacerbation of COPD compared to those with stable COPD[42]
Higher sputum-to-serum ratio of H2S in COPD subjects with acute exacerbation comparative with those with stable disease[42]
Lower serum H2S levels in patients with COPD who required antibiotics treatment[43]
AsthmaIn children, serum H2S concentration was significantly decreased compared to healthy subjects and correlated positively with FEV1[17]
In adults, exhaled H2S was lowest in eosinophilic asthma correlated positively with FEV1[46]
Pulmonary fibrosisH2S suppress human fibroblast migration, proliferation and phenotype transform stimulated by fetal bovine serum and growth factors and inhibits the TGF-β1-induced differentiation of fibroblasts to myofibroblasts[53]