Role of hydrogen sulphide in airways

Table 2 The effect of hydrogen sulfide on airway smooth muscle function

Tissue	H2S effects	Involved mechanism	Ref.
Porcine peripheral bronchiols	Relaxation	Alteration in K+ channels activity	[20]
Guinea pig main bronchus	Slight relaxation		[21]
Guinea pig airways	Neurogenic inflammatory responses	Stimulation of TRPV1 receptors on sensory nerves endings	[23]
Mouse main bronchus	Relaxation	Independent of NK1/NK2 tachykinin receptors, KATP channels, production of NO, cGMP and prostaglandins	[21]
Mouse lung	Neurogenic inflammation	Stimulation of NK1 and Substance P release	[24]
Mouse small intrapulmonary airways	Relaxation	Inhibition of Ca2+ release from intracellular stores through InsP3 receptors	[27]
Mouse tracheal smooth muscle cells	Relaxation	Activation of BKCa channels	[26]
Rat trachea	Relaxation	Independent of KATP channels, β-adrenoceptors, epithelium and production of NO, cGMP and prostaglandins	[22]
Human ASMCs	Relaxation	Opening of KATP channels	[29]
Isolated human airway smooth muscle cells	Relaxation	Inhibition of ERK-1/2 and p38 MAPK phosphorylation	[30]
	Decrease of cell proliferation and IL-8 release

H₂S: Hydrogen sulfide; TRPV: Transient receptor potential vanilloid channels.