Effectiveness of adaptive servo-ventilation

Table 3 Clinical trials assessing the effects of adaptive-servo ventilation on cardiac function in heart failure patients with central sleep apnea and coexisting obstructive sleep apnea

Ref.	Study design	n	Duration (mo)	Baseline		Device usage (h)	Changes
				AHI	EF		AHI	EF
Kasai et al[40]	RCT
	CPAP	15	3	38.6	36	4.4	-23.2	1.9
	f-ASV	16		36.3	35.7	5.25	-35.4	9.1
Randerath et al[41]	RCT
	CPAP	34	12	41	43	4.3	-24.0	4.9
	f-ASV	36		47	47	5.2	-36.0	-1.9
Yoshihisa et al[42]	RCT
	Control	18	6	36	54	-	-8.2	-2.0
	v-ASV	18		37	56.1	5.6	-30.2	5.1
Birner et al[43]	RCT
	Control	35	3	43	29	-	0	3.0
	f-ASV	37		52	30	4.2	-41.0	1.0

AHI: Apnea-hypopnea index; ASV: Adaptive-servo ventilation; CPAP: Continuous positive airway pressure; EF: Ejection fraction; f-ASV: Flow-targeted ASV; v-ASV: Volume-targeted ASV; RCT: Randomized controlled trial.