Effectiveness of adaptive servo-ventilation

Table 2 Clinical trials assessing the effects of adaptive-servo ventilation on cardiac function in heart failure patients with central sleep apnea

Ref.	Study design	n	Duration (mo)	Baseline		Device usage (h)	Changes
				AHI	EF		AHI	EF
Pepperell et al[36]	RCT
	Subtherapeutic	15	1	17.7	35.7	3.9	-3	0.5
	Therapeutic	15		21.9	36.5	5.0	-16.5	1.8
Philippe et al[3]	RCT
	CPAP	13	6	40.5	30.0	4.2	-20	-2
	ASV	12		47.0	29.0	5.8	-45	7
Fietze et al[37]	RCT
	Bi-level PAP	15	1.5	34.9	25.5	4.81	-18.5	5.6
	ASV	15		31.7	24.6		-20.5	1.9
1Kasai et al[4]	RCT
	CPAP-mode	11	3	23.02	33.0	3.3	0.1	-1
	ASV-mode	12		25.02	32.0	4.7	-23	5.8

¹Patients with residual AHIs ≥ 15 on CPAP were included;

²AHIs on CPAP were described. AHI: Apnea-hypopnea index; ASV: Adaptive-servo ventilation; Bi-level PAP: Bi-level positive airway pressure; CPAP: Continuous positive airway pressure; EF: Ejection fraction; RCT: Randomized controlled trial.