Copyright
©The Author(s) 2015.
World J Respirol. Jul 28, 2015; 5(2): 102-111
Published online Jul 28, 2015. doi: 10.5320/wjr.v5.i2.102
Published online Jul 28, 2015. doi: 10.5320/wjr.v5.i2.102
Table 4 Prospective trials of first line platinum-based chemotherapy in elderly patients affected by advanced non-small-cell lung cancer
| Ref. | Regimen | Phase | Age (yr) | No. of patients | Efficacy |
| Gridelli et al[44] | CDDP + GEM | I/II | ≥ 70 | 159 | OS 43.6 wk |
| PFS 25.3 wk | |||||
| RR 43.5% | |||||
| CDDP + VNR | OS 33.1 wk | ||||
| PFS 21.1 wk | |||||
| RR 36.1% | |||||
| Abe et al[43] | CDDP + DOC | III | > 70 | 221 | OS 13.3 wk |
| vs | OS 17.3 wk | ||||
| DOC | |||||
| Biesma et al[53] | CARBO + GEM | III | ≥ 70 | 181 | OS 8.6 mo |
| vs | RR 27% | ||||
| CARBO + PAC | OS 6.9 mo | ||||
| RR 19% | |||||
| Quoix et al[54] | GEM or VNR | III | ≥ 70 | 451 | OS 6.2 mo |
| vs | RR 10.9% | ||||
| CARBO + PAC | OS 10.3 mo | ||||
| RR 29.5% |
- Citation: Buffoni L, Consito L, Filippi AR, Ruffini E, Solidoro P, Bironzo P, Satolli MA, Schena M, Ciuffreda L. Advanced non-small cell lung cancer in elderly patients: A review. World J Respirol 2015; 5(2): 102-111
- URL: https://www.wjgnet.com/2218-6255/full/v5/i2/102.htm
- DOI: https://dx.doi.org/10.5320/wjr.v5.i2.102