Role of chronic obstructive pulmonary disease in lung cancer pathogenesis

Table 2 Oxidative stress genes with good evidence that they contribute to both chronic obstructive pulmonary disease and lung cancer

Gene	Polymorphism	COPD risk	Lung cancer risk	Ref.
EPHX1	Rs2234922 (A139G) and haplotypes	↑Asians ↔ Caucasians	↑	[88,89]
GSTM1	Null genotype	↑	↑	[28,90]
SOD3	Rs1799896	↑	In vitro evidence of SOD3 ↑risk	[90-92]

COPD: Chronic obstructive pulmonary disease; EPHX1: Epoxide hydrolase; GSTM1: Glutathione S-transferase M1; SOD3: Superoxide dismutase 3.