High-frequency electrical stimulation of cervical vagi reduces airway response to methacholine

Figure 6 Cardiovascular and airway responses to 2 min vagal high-frequency electrical stimulation after exposure to methacholine aerosal (100 μg/mL per minute for 2 min). A: HESm1-evoked responses in an Ova-treated guinea pig about 2 min after initiation of methacholine (MCh) challenge, in which the baseline values of total lung resistance (R_L) and dynamic pulmonary compliance (C_dyn) were 0.1 cmH₂O s/mL and 0.4 mL/cmH₂O respectively; B: The averaged data of MABP, HR, R_L and C_dyn from three guinea pigs (five trials) are illustrated in panel. In both panels, the traces are arterial blood pressure (ABP/MABP), heart rate (HR), R_L, and C_dyn. n = 5 trials (3 guinea pigs); Mean ± SE; ^aP < 0.05, high-frequency electrical stimulation (HES)-evoked responses vs the data before electrical stimulation presented as “0”.