State of the art management of diabetic macular edema

Table 4 Summary of the study using intravitreal Aflibercept for treatment of diabetic macular edema

Name of study	Purpose	Study design	Out comes measures	IVA Dose	Interval of injection	Naive or refractory /DME	Duration of study	Number of eyes	Treatment regimen	Results
DA VINCI[84,85]	IVVTE for DME	RCT	IVA f or DME	0.5 and 2 mg	1 and 2 mo	Naïve or refractory	1 yr	221	Group 1 (IVVTE1, n = 44 eyes): IVVTE, 0.5 mg every 4 wk Group 2 (IVVTE2, n = 44 eyes): IVVTE, 2 mg every 4 wk Group 3 (IVVTE3, n = 42 eyes): IVVTE, 2 mg for 3 initial mo then every 8 wk Group 4 (IVVTE4, n = 45 eyes): IVVTE, 2 mg for 3 initial months then as needed Group 5 (L, n = 44 eyes): laser photocoagulation Laser modified ETDRS protocol	BCVA changes (letters) P value IVVTE1 +8.6 0.005 IVVTE2 +11.4 < 0.0001 IVVTE3 +8.5 0.008 IVVTE4 +10.3 0.0004 L +2.5 CMT(μm) IVVTE1 -144.6 0.0002 IVVTE2 -194.5 < 0.0001 IVVTE3 -127.3 0.007 IVVTE4 -153.3 < 0.0001 L -67.9

DME: Diabetic macular edema; IVTL: Intravitreal triamcinolone plus laser; IVVTE: Intravitreal VEGF Trap Eye; IVA: Intravitral aflibercept.