Copyright
©The Author(s) 2015.
World J Ophthalmol. Feb 12, 2015; 5(1): 1-15
Published online Feb 12, 2015. doi: 10.5318/wjo.v5.i1.1
Published online Feb 12, 2015. doi: 10.5318/wjo.v5.i1.1
Table 4 Overview of mucous membrane pemphigoid and pseudopemphigoid as caused by the pemphigus disease
| MMP | Pseudopemphigoid | ||
| PNP | OPV | ||
| Location | Subepidermal | Intraepidermal | Intraepidermal |
| DIF | IgG/IgA/IgM/C3 | IgG/C3 | IgG/C3 |
| IIF on salt-split skin | Dermal, epidermal, or combined depending on antigen | Not applicable | Not applicable |
| IEM: ultrastructural location of antigen | Lamina lucida | Hemidesmosomes | Desmosomes |
| Lamina densa | Desmosomal plaques | ||
| Sublamina densa (anchoring fibrils) | Lamina lucida | ||
| Immunoblot: determination of antigen | Bullous pemphigoid antigen 1 (Bullous Pemphigoid 230) Bullous pemphigoid antigen 2 (Bullous Pemphigoid 180, type XVII collagen) Type VII collagen (290 kDa) Laminin332, epiligrin, or laminin 5 α3β3γ2 (165, 145, 140, 105 kDa) Laminin 6 (α3) Integrin beta 4 45 kDa epithelial protein 130 kDa epithelial protein 140 kDa epithelial protein 205 kDa epithelial protein 168 kDa epithelial protein Uncein LAD-1 (97/120 kDa) | Plakin protein family: Desmoplakin I (250 kDa) Bullous pemphigoid antigen 1 (230 kDa) Desmoplakin II and envoplakin (210 kDa) Periplakin (190 kDa) Plectin (500 kDa) Desmocollin 2 (105 kDa) Desmocollin 3 α2-macroglobulin-like-1 (A2LM1, 170 kDa) Desmoglein 1 (160 kDa) Desmoglein 3 (130 kDa) | Desmoglein 1 (160 kDa) Desmoglein 3 (130 kDa) |
| Increased malignancy | Yes - solid malignancies (laminin 332 subtype) | Yes - lymphoproliferative malignancies | -- |
- Citation: Huang LC, Wong JR, Alonso-Llamazares J, Nousari CH, Perez VL, Amescua G, Karp CL, Galor A. Pseudopemphigoid as caused by topical drugs and pemphigus disease. World J Ophthalmol 2015; 5(1): 1-15
- URL: https://www.wjgnet.com/2218-6239/full/v5/i1/1.htm
- DOI: https://dx.doi.org/10.5318/wjo.v5.i1.1