Variation in use of menopausal hormone treatment on risk of health outcomes

Table 3 Variation of use of menopausal hormone treatment and risk of serious outcomes : Age of patient and duration of use

	Relative risk estimate (95%Cl)
	Coronaryartery disease	Stroke	Peripheral artery disease	Breast cancer
Age of patient when treatment started (yr)
20-39	0.48 (0.07, 3.35)	0.68 (0.09, 5.35)	1.57 (0.19, 12.79)	0.83 (0.11, 6.57)
	P = 0.47	P = 0.72	P = 0.67	P = 0.87
40-49	1.14 (0.55, 2.37)	0.98 (0.41, 2.37)	2.25 (0.85, 5.96)	0.66 (0.22, 1.97)
	P = 0.72	P = 0.97	P = 0.10	P = 0.45
50-59	0.83 (0.37, 1.87)	1.18 (0.51, 2.75)	1.63 (0.55, 4.79)	0.87 (0.32, 2.38)
	P = 0.65	P = 0.69	P = 0.37	P = 0.78
60-79	7.7 (2.85, 20.76)	2.19 (0.59, 8.11)	5.01 (1.27, 19.80)	1.67 (0.36, 7.77)
	P < 0.001	P = 0.24	P = 0.02	P = 0.52
Age of patient when treatment stopped (yr)
20-39	1.36 (0.38, 4.88)	1.22 (0.27, 5.56)	2.79 (0.57, 13.53)	1.48 (0.32, 6.85)
	P = 0.64	P = 0.80	P = 0.20	P = 0.61
40-49	0.48 (0.18, 1.27)	0.54 (0.18, 1.59)	0.92 (0.25, 3.37)	0.32 (0.97, 1.41)
	P = 0.50	P = 0.26	P = 0.90	P = 0.13
50-59	1.3 (0.61, 2.80)	1.24 (0.51, 3.00)	2.83 (1.06, 7.60)	1.75 (0.74, 4.16)
	P = 0.50	P = 0.64	P = 0.04	P = 0.20
60-79	4.98 (2.19, 11.55)	2.99 (1.11, 8.08)	4.18 (1.24, 14.14)	NC
	P < 0.001	P = 0.03	P = 0.02
Duration of use (yr)
< 1	1.1 (0.24, 5.04)	NC	3.59 (0.72, 17.75)	1.91 (0.40, 8.98)
	P = 0.90		P = 0.12	P = 0.41
1-5	0.76 (0.31, 1.87)	1.28 (0.53, 3.11)	1.18 (0.32, 4.34)	0.85 (0.28, 2.57)
	P = 0.55	P = 0.59	P = 0.81	P = 0.77
6-10	2.12 (0.90, 5.03)	0.3 (0.04, 2.32)	1.43 (0.31, 6.74)	0.37 (0.40, 2.85)
	P = 0.09	P = 0.25	P = 0.65	P = 0.34
11-15	0.75 (0.26, 2.20)	1.69 (0.65, 4.38)	3.14 (1.04, 9.50)	0.95 (0.27, 3.35)
	P = 0.60	P = 0.28	P = 0.04	P = 0.94
16-20	2.75 (0.93, 8.11)	1.29 (0.28, 5.92)	NC	0.74 (0.09, 5.84)
	P = 0.07	P = 0.74		P = 0.78
21-25	2.89 (0.73, 11.41)	2.44 (0.50, 11.92)	5.57 (1.07, 28.92)	1.33 (0.16, 10.96)
	P = 0.13	P = 0.27	P = 0.04	P = 0.79
26+	1.28 (0.15, 10.97)	1.83 (0.21, 15.80)	10.03 (1.75, 57.58)	NC
	P = 0.82	P = 0.58	P = 0.01

NC: No convergence due to small numbers.