Overview of embryonal rhabdomyosarcoma of cervix in women over 40-year-old

Table 3 Case-series of cervical embryonal rhabdomyosarcomas reporting on > 4 patients, of whom at least one was > 40-year-old

AuthorYearCases	Women ≤40-year-old				Women > 40-year-old
	n	Age,yr	1st treatment(n)	Follow-up(yr)	n	Age,yr	1st treatment(n)	Follow-up(yr)
Montag et al[5] 1986 n = 4	3	18, 21, 26	TAH (3), BSO (2), LND (2); CT (3)	Alive NED at 1.4 yr, 7 yr, and 8 yr	1	42	TAH-BSO-LND; RT + BT	No local recurrence, but lung metastasis at 9 mo, resection and CT; Alive NED after 10 yr
Brand et al[12] 1987 n = 4	3	1.4, 17, 17	TAH (2), BSO (1), LND (1), no surgery (1); CT (2), RT (1)	Died WD at 0.5 yr (case no RT); Alive NED at 1 yr and 8 yr	1	48	TAH-BSO; CT	Vaginal recurrence at 2 mo, pelvic RT + intravaginal brachytherapy; Alive NED after 22 yr
Ferguson et al[13] 2007 n = 8	3	17, 22, 32	Unknown (1), TAH (2), BSO (1), LND (2); CT (2), RT (2)	Died WD at 1.8 yr (case CT + RT); Alive NED at 0.2 yr and 10 yr (RT)	5	46, 51, 52, 56, 58	TAH-BSO-LND (4); TAH-LND (1); CT (2); RT (2); BT (2)	Dead WD (2) 1 yr and 1.4 yr after; Alive NED (3) at 0.6 yr, 2 yr, and 3 yr
Kriseman et al[14] 2012 n = 11	9	3, 12, 13, 17, 18, 18, 27, 33, 34	No surgery (2), cone biopsy (6), polypectomy (1), TAH-BSO (1), CT (8), RT (1)	No FU (4), Died at date not reported (1) Alive NED (5) at 0.3 yr, 0.5 yr, 2 yr, 3 yr, and 10 yr	2	49	TAH-BSO; CT; RT	No recurrence, died after 6 yr from the second primary tumor, adenocarcinoma of parotid;
						52	Cone biopsy; no adjuvant therapy	Alive NED after 1.5 yr
Li et al[15] 2013 n = 20	7	20, 21, 23, 26, 29, 29, 31	Unknown (2), polypectomy (4), TAH (1) CT (3)	No FU (5); Alive NED (3) at 3.5 yr, 6 yr, and 8 yr	13	54	TAH	Alive WD (vaginal recurrence) at 0.4 yr
						46	TAH; CT	Alive NED at 3 yr
						73	Polypectomy	Died at 0.4 yr with lung metastasis and a second primary tumor, ductal breast carcinoma
						43, 44, 46, 47 48, 49, 51, 56, 56, 89	Polypectomy (7); TAH (2); Unknown (1)	No FU data
Summary n = 47	25	Median age 21 yr (range 1-34 yr)	Surgery: TAH 9/21 (42.9%), CT: 18/20 (90.0%), RT: 4/19 (21.1%)	No FU: 8 (32.0%), Alive: 15/17(88.0%), 0 WD, Median FU, 3.5 yr Died: 3/17 (17.6%), at median 1.1 yr	22	Median age 50 yr (range 42-89 yr)	Surgery: TAH 12/14 (85.7%) CT: 6/11 (54.5%) RT: 4/11 (36.4%)	No FU: 10 (45.5%) Alive: 8/12 (66.7%), 3 WD, Median FU 2.6 yr Died: 4 (33.3%), at median 1.2 yr

TAH: Total abdominal hysterectomy; BSO: Bilateral salpingo-oophorectomy; LND: Lymph node dissection; NED: No evidence of disease; WD: With disease; CT: Chemotherapy; RT: External radiotherapy; BT: Brachytherapy; FU: Follow-up.