Intrauterine growth restriction and genetic determinants - existing findings, problems, and further direction

Table 4 AGT genotype and placental findings[42]

AGT genotype	MM	MT	TT
No. of placentas	8	13	14
Clinical findings
Maternal age (yr)	26.0 ± 4.7	26.6 ± 6.6	29.8 ± 6.5
Gestational age (wk)	36.2 ± 4.5	36.6 ± 1.9	36.7 ± 3.1
Fetal birth wt. (g)	2730 ± 967	2642 ± 541	2620 ± 535
Placental quantitative findings:
Number of villi (mm2)	155.3 ± 14.1	145.8 ± 28.0	146.3 ± 27.7
Villous CS area (μm2/villous)	4422.2 ± 550.0	4400.9 ± 813.5	4248.6 ± 1191.9
Villous volume/1 cm3 placenta (cm3)	0.668 ± 0.034	0.626 ± 0.022b	0.587 ± 0.059bc
Capillary volume/1 cm3 placenta (cm3)	0.131 ± 0.029	0.107 ± 0.034	0.070 ± 0.030b
Intervillous volume/1 cm3 placenta (cm3)	0.332 ± 0.034	0.374 ± 0.022b	0.413 ± 0.059bc
Placental quantitative analysis:
Volume of trimmed placenta (cm3)	324.8 ± 128.0	355.2 ± 80.3	374.1 ± 70.2
Villous total volume per placenta (cm3)	215.8 ± 81.8	222.1 ± 50.7	219.9 ± 52.6
Intervillous space per placenta (cm3)	108.9 ± 47.8	133.1 ± 31.1	154.2 ± 38.6a
Villous capillary volume per placenta (cm3)	45.1 ± 27.4	41.4 ± 23.2	26.6 ± 14.4a
Percentage of villous capillary volume (%)	19.81 ± 5.12	17.41 ± 7.3	12.06 ± 5.45a
Villous surface area per placenta (m2)	9.029 ± 3.285	9.560 ± 2.031	10.370 ± 2.725
Villous surface per 1 g plac. Villi (cm2)	390.6 ± 35.0	401.6 ± 40.5	438.6 ± 73.8

^aP < 0.05,

^bP < 0.01 vs MM;

^cP < 0.05 vs MT.