Aquaporin-4 and spinal cord injury

Table 3 Studies utilizing aquaporin-4 null mice

Ref.	Species	Model	Device	Parameters	Level	AQP4 IHC	Water content	Behavioral outcome
Kimura et al[98]	CD1 AQP4 -/- female mice, AQP4 +/+	Contusion	IH Impactor	60 kdyn	T10		↑ levels in -/- compared to +/+	↓ in -/- compared to +/+ (BMS, foot print analysis, bladder function)
Saadoun et al[95]	CD1 and BL/6 AQP4 -/-, AQP +/+	Compression	Dumont 5 forcepts	1 mm separation, 2 min hold	T6	↑ AQP4 in +/+ SCI at 2 d	↓ levels in -/- compared to +/+	↑ in -/- compared to +/+ (BMS, foot print analysis)
Wu et al[68]	CD1 AQP4 -/-, AQP4 +/+	Transection	Louisville Impactor System Apparatus	0.8 mm depth, right hemisection	C4	↓ AQP4 in +/+ SCI at 2 d and 7 d	↑ levels in both -/- and +/+ at 3 d
						↑ AQP4 in +/+ SCI at 42 d	↑ levels in -/- compared to +/+ at 3 d

AQP4: Aquaporin-4; IH: Infinite horizons; BMS: Basso mouse locomotor scale; SCI: Spinal cord injury.