Mechanical transduction by ion channels: A cautionary tale

Figure 5 Structured illumination image of an human embryonic kidney cell cotransfected with human PIEZO1 channels labelled green and TREK-1 channels labelled red using green fluorescent protein mutants. Notice that the channels are in different structural domains and thus feel different forces. Notice also that TREK-1 tends to follow underlying cytoskeletal fibers. (Courtesy Gottlieb P).