Hypocretin (orexin) pathology in Alzheimer’s disease

Table 1 Important findings shows role of hypocretin in Alzheimer’s disease

Ref.	Year	Major findings
Friedman et al[28]	2007	Increased wake fragmentation found in those with lower hypocretin-1
Kang et al[29]	2009	Amyloid-beta dynamics are regulated by hypocretin and the sleep-wake cycle
Fronczek et al[27]	2011	40% hypocretin cell loss in Alzheimer's disease
Slats et al[30]	2012	Association between hypocretin-1 and amyloid-β42 cerebrospinal fluid levels
Roh et al[8]	2014	Modulation of hypocretin and its effects on sleep to modulate Aβ pathology
Liguori et al[7]	2014	Increased hypocretin level correlates with sleep disruption and cognitive decline in Alzheimer's disease