Protein seeding in Alzheimer’s disease and Parkinson’s disease: Similarities and differences

Figure 1 Fibrillar amyloid-beta peptide and alpha-synuclein. A and B: Amyloid-beta (10 mg/mL) was aggregated at room temperature for 72 h with shaking; C and D: α-synuclein (2 mg/mL) was aggregated by incubation at 37 °C for 144 h with shaking. Aggregation leads to formation of fibrils with varying structures. Fibrils were negatively stained with 2% phosphotungstic acid and their formation was confirmed using Transmission Electron Microscopy at 75 kV. Images display 40000 × magnification.