Variation in experimental autoimmune encephalomyelitis scores in a mouse model of multiple sclerosis

Table 2 Differences in experimental autoimmune encephalomyelitis scores among researchers

	Swanborg[18]	Matsumoto et al[19]	Yamamura et al[20]	Sobel et al[21]	Kalyvas et al[22]	Mendel et al[23]	Pollak et al[24]	Takeuchi et al[25]
Strain	Lewis rat	Lewis rat	C57BL/6J mice	SJL/J mice	C57BL/6J mice	C57BL/6J mice	SLJ/J mice	C57BL/6J mice
Antigen	MBP	MBP	MOG35-55	PLP131-151	MOG35-55	MOG	PLP131-151	MOG35-55
0	ND	ND	No clinical signs	No disease	Normal	No clinical signs	No neurological signs	No detectable signs of paralysis
1	Loss of tail tonicity	Flaccid tail	Loss of tail tonicity	Decreased tail tone or slightly clumsy gait	Flaccid tail	Loss of tail tonicity	Tail weakness	Completely limp tail
2	Definite hind quarter weakness	Mild paraparesis	Impaired righting reflex	Tail atony and/or moderately clumsy gait and/or poor righting ability	Mild hindlimb paralysis	Flaccid tail	Tail paralysis	Loss of the righting reflex
3	Hind leg paralysis	Severe paraparesis	Partial hindlimb paralysis	Limb weakness	Severe hindlimb weakness	Hind leg paralysis	Loss of righting reflex	Partial hind limb paralysis
4	ND	Moribund condition	Total hindlimb paralysis	Limb paralysis	Hindlimb paralysis	Hind leg paralysis with hind body paresis	Hind limb paresis/paralysis	Complete hind limb paralysis
5	ND	ND	ND	Moribund	Hindlimb paralysis and forelimb weakness or moribund	Hind and fore leg paralysis	Quadriplegia (immobility)	Total paralysis of allfour limbs
6	ND	ND	ND	ND	ND	Death	Death	Death

ND: Not defined.