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World J Neurol. Sep 28, 2013; 3(3): 56-61
Published online Sep 28, 2013. doi: 10.5316/wjn.v3.i3.56
Published online Sep 28, 2013. doi: 10.5316/wjn.v3.i3.56
Score | EAE signs | Observation |
0 | No signs of EAE | Hind legs are extended; tail extends up and moves; tail wraps around cylindrical object; normal gait |
0.5 | Partially limp tail | Hind legs are extended; tip of tail droops and/or does not wrap around cylindrical object; normal gait |
1 | Paralyzed tail | Hind legs are extended; tail droops and does not wrap around cylindrical object; normal gait |
2 | Loss in coordinated movement; hind limb paralysis | Hind legs contract when held at the base of tail; mouse walks with uncoordinated movement; hind limbs reflex when toes are pinched; limp tail |
2.5 | One hind limb paralysis | Mouse drags one hind limb; one hind limb does not respond to pinch; limp tail |
3 | Both hind limbs paralysis | Mouse drags both hind limbs; both hind limbs do not respond to toe pinch; limp tail |
3.5 | Hind limb paralysis; weakness in forelimbs | Mouse drags hind limbs but has difficulty using forelimbs to pull body; forelimbs respond to toe pinch; limp tail |
4 | Forelimbs paralysis | Mouse cannot move; forelimbs do not respond to toe pinch; limp tail |
5 | Moribund | No movement; cold to the touch; altered breathing |
- Citation: Takeuchi C, Yamagata K, Takemiya T. Variation in experimental autoimmune encephalomyelitis scores in a mouse model of multiple sclerosis. World J Neurol 2013; 3(3): 56-61
- URL: https://www.wjgnet.com/2218-6212/full/v3/i3/56.htm
- DOI: https://dx.doi.org/10.5316/wjn.v3.i3.56