Depression in adults with epilepsy: Relationship to psychobiological variables

Table 2 Significance between patients and control subjects in scores of depression, hormones and neurotransmitters in relation to epilepsy related and treatment related variables

Epilepsy-related variables	BDI-II	HAM-A	Free testosterone	SHBG	Serotoni (n)	Noradrenaline	Adrenaline
Type of epilepsy
Generalized (n = 39)
P1	0.016	0.538	0.347	0.476	0.001	0.169	0.008
Focal ( n = 66)
P1	0.102	0.458	0.816	0.125	0.01	0.049	0.004
P2	0.364	0.861	0.212	0.65	0.093	0.563	0.505
Focal epilepsies
Frontal ( n = 26)
P1	0.076	0.8	0.567	0.255	0.019	0.253	0.065
Temporal ( n = 36)
P1	0.33	0.494	0.75	0.231	0.008	0.039	0.014
P3	0.387	0.77	0.053	1	0.884	0.683	0.456
Parietal ( n = 4)
P1	0.065	0.658	0.325	0.467	0.822	0.385	0.184
P3	0.483	0.668	0.095	0.564	0.567	0.655	1
P4	0.168	0.635	0.538	0.229	0.112	1	0.596
Side of epileptic activity
Right ( n = 29)
P1	0.011	0.896	0.631	0.202	0.027	0.127	0.023
Left ( n = 37)
P1	0.474	0.388	0.95	0.282	0.012	0.047	0.017
P5	0.149	0.518	0.197	0.248	0.754	0.685	0.779
CBZ ( n = 55)
P1	0.07	0.069	0.512	0.61	0.011	0.085	0.028
P6	0.725	0.224	0.457	0.205	0.196	0.713	0.304
P7	0.03	0.006	0.334	1	0.293	0.465	0.237
VPA ( n = 28)
P1	0.443	0.784	0.451	0.129	0.001	0.044	0.007
P7	0.032	0.069	0.432	0.813	0.859	0.391	0.609
Polytherapy ( n = 22)
P1	0.001	0.084	0.936	1	0.017	0.349	0.02
Controlled ( n = 28)
P1	0.11	0.001	0.873	0.873	0.013	0.805	0.042
P8	0.01	0.026	0.024	0.462	0.658	0.047	0.094
P9	0.0001	0.0001	0.067	0.564	0.534	0.086	0.659
Partially uncontrolled ( n = 23)
P1	0.06	0.6	0.352	0.265	0.014	0.068	0.005
P9	0.3	0.173	0.873	0.624	0.567	0.951	0.164
Uncontrolled ( n = 54)
P1	0.000	0.253	0.254	0.79	0.004	0.017	0.012

CBZ: Carbamazepine; VPA: Valproate; BDI-II: Beck depression inventory – 2nd Edition; HAM-A: Hamilton anxiety rating scale; SHBG: Sex hormone binding globulin; P1: Patients vs controls; P2: Generalized vs focal; P3: Versus frontal; P4: Versus temporal; P5: Right vs left; P6: CBZ vs VPA; P7: Versus polytherapy; P8: Versus partially controlled; P9: Versus uncontrolled.