Pleomorphic cutaneous xanthomas disclosing homozygous familial hypercholesterolemia

Figure 5 Tuberous xanthomas. They are very common and clinically variable. They may appear as firm, painless, red-yellow, waxy-appearing nodules located in the dermis and subcutaneous tissue, from few millimeters to several centimeters in size. They often present with a cobblestone-like pattern developing around the pressure areas such as: A and B: The knees; C: Malleolus; D: Buttocks. Lesions can join together to form multilobated masses.