Clinical pharmacokinetics profile of ivermectin 1% cream after dermal applications on the face

Table 3 Pharmacokinetic parameters of ivermectin obtained after topical application of ivermectin 1% cream once a day in subjects with papulopustular rosacea (maximal use pharmacokinetic study)

ParametersMean ± SD	Day 01	Day 72	Day 14	Day 21	Day 28
Pre-dose/Cmin (ng/mL)	0.37 ± 0.21	1.17 ± 0.88	1.26 ± 0.533	1.36 ± 0.663	1.36 ± 0.63
Cmax (ng/mL)	0.69 ± 0.49	NA	2.10 ± 1.04	NA	1.74 ± 0.77
Tmax (h)	9 ± 6	NA	10 ± 8	NA	11 ± 4
AUC0-24 h (ng × h/mL)	9.3 ± 5.4	NA	36 ± 16	NA	35 ± 14

NA: Not applicable; Pre-dose/C_min: Residual drug concentration (pre-dose level); AUC_{0-24 h}: Area under the plasma concentration-time curve from pre-application (T0) through to 24 h;

¹N: 17;

²N: 13;

³N: 14.