Clinical pharmacokinetics profile of ivermectin 1% cream after dermal applications on the face

Table 2 Pharmacokinetic parameters obtained after topical applications of ivermectin 1% cream in healthy volunteer subjects

Group	Time Point	Cmax(ng/mL)	Tmax(h)	AUC0-12 h(ng × h/mL)	AUC0-24 h(ng × h/mL)
1: Single dose	NA	0.49 ± 0.15	9 ± 3	3.8 ± 1.4	8.3 ± 2.5
2: QD 4 wk treatment	Day 0	0.41 ± 0.17	10 ± 5	3.1 ± 1.5	6.9 ± 2.9
	Day 14	0.93 ± 0.35	NA	9.8 ± 3.4	19 ± 7
	Day 28	1.08 ± 0.43	NA	11 ± 5	21 ± 8
3: BID 4 wk treatment	Day 0	0.34 ± 0.16	11 ± 2	2.6 ± 1.5	NA
	Day 14	1.70 ± 0.66	NA	18 ± 6	NA
	Day 28	1.90 ± 0.76	NA	20 ± 9	38 ± 17

NA: Not applicable; AUC_{0-12 h}: Area under the plasma concentration-time curve from pre-application (T0) through to 12 h; AUC_{0-24 h}: Area under the plasma concentration-time curve from pre-application (T0) through to 24 h.