Copyright
©The Author(s) 2016.
World J Dermatol. Feb 2, 2016; 5(1): 17-51
Published online Feb 2, 2016. doi: 10.5314/wjd.v5.i1.17
Published online Feb 2, 2016. doi: 10.5314/wjd.v5.i1.17
Table 6 Drugs interacting with retinoids
Interacting drug | Mechanism/comments |
Drugs that may increase retinoids levels and/or toxicity | |
Vitamin A | Induces hypervitaminosis A like toxicities |
Tetracycline, doxycycline and minocycline | Increase pseudotumour cerebri risk |
Macrolides, Azoles, etc. | Other CYP 3A4 inhibitors increase its level |
Drugs that may reduce retinoids level | |
Rifampicin, rifabutin | Induction of CYP 3A4 |
Anticonvulsants-phenytoin, Phenobarbital, carbamazepine | Induction of CYP 3A4 |
Drugs that may synergistically increase hepatotoxicity | |
Methotrexate | Common target organ for toxicity-liver |
Alcohol | Common target organ for toxicity-liver |
Drugs whose levels are changed by retinoids | |
Cyclosporine A | Cyclosporine A levels are increased via competition for CYP 3A4 |
- Citation: Mahajan VK. Psoriasis treatment: Unconventional and non-standard modalities in the era of biologics. World J Dermatol 2016; 5(1): 17-51
- URL: https://www.wjgnet.com/2218-6190/full/v5/i1/17.htm
- DOI: https://dx.doi.org/10.5314/wjd.v5.i1.17