Knowledge explosion for monogenic skin diseases

Table 1 Classification of the clinical variants within the disease spectrum caused by CYLD mutation

Name of clinical variant	Familial cylindromatosis	Brooke-Spiegler syndrome	Multiple familial trichoepithelioma type 1
Clinical symptoms	Cylindromas	Cylindromas Trichoepitheliomas Spiradenomas	Trichoepitheliomas
Genetic background	Any type of mutation	Any type of mutation	Any type, but mainly missense mutations