Pathogenesis and diagnosis of contact dermatitis: Applications of reflectance confocal microscopy

doi:10.5314/wjd.v3.i3.45

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Aug 2, 2014 (publication date) through Apr 18, 2025

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World Journal of Dermatology

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2218-6190

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Dermatol. Aug 2, 2014; 3(3): 45-49
Published online Aug 2, 2014. doi: 10.5314/wjd.v3.i3.45

Table 2 Diagnostic features to differentiate irritant contact dermatitis and allergic contact dermatitis with reflectance confocal microscopy

	ICD	ACD
Stratum corneum	Parakeratosis: +++ (early stage) Corneocyte detachment: +++ (early stage)	-
Stratum granulosum and spinosum (1^st wk)	Exocytosis: +++ Spongiosis: +++ Necrosis: +++ Vesicles: +++	Exocytosis: + Spongiosis: + Necrosis: + Vesicles: ++
Stratum granulosum and spinosum (2^nd wk)	Exocytosis: +++ Spongiosis: +++ Necrosis: +++ Vesicles: +++	Exocytosis: ++++ Spongiosis: +++ Necrosis: +++ Vesicles: +++
Superficial perivascular infiltrate	+	+
Capillary dilation in the dermal papillae and leukocyte traffic	+	+

+++: Strong positive association; ++: Moderate positive association; +: Positive association; –: Negative association. ACD: Allergic contact dermatitis; ICD: Irritant contact dermatitis.

Citation: Suárez-Pérez JA, Bosch R, González S, González E. Pathogenesis and diagnosis of contact dermatitis: Applications of reflectance confocal microscopy. World J Dermatol 2014; 3(3): 45-49
URL: https://www.wjgnet.com/2218-6190/full/v3/i3/45.htm
DOI: https://dx.doi.org/10.5314/wjd.v3.i3.45