Paroxetine vs pregabalin for the management of neuropathic pain in multiple sclerosis

Table 1 Study eligibility requirements

Inclusion criteria	Exclusion criteria
Males and females 18-65 years old	Breastfeeding
Clinically definite RRMS	History of alcohol or other substance abuse
EDSS ≤ 6.5	Significant hepatic/renal insufficiency
VAS score for NPP symptoms > 5	Significant cardiac disease (CHF, arrhythmia); hypertension
Pain present for at least 3 mo	Hypersensitivity/allergy to study medications or their derivatives
Negative serum pregnancy test	No current therapeutic duplications No history of psychotic/non-psychotic emotional disorders

Inclusion and exclusion criteria for enrolment in the study are noted above. RRMS: Relapsing-remitting multiple sclerosis; EDSS: Expanded Disability Status Scale; NPP: Neuropathic pain; VAS: Visual analogue scale; CHF: Congestive heart failure.