Recently highlighted nutraceuticals for preventive management of osteoarthritis

doi:10.5312/wjo.v9.i11.255

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World Journal of Orthopedics

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2218-5836

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Orthop. Nov 18, 2018; 9(11): 255-261
Published online Nov 18, 2018. doi: 10.5312/wjo.v9.i11.255

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Figure 5 Mechanisms of heme oxygenase-1 upregulation by carnosic acid. CA induces the expression of HO-1 by: Activation of the Nrf2 transcription factor, downregulation of Bach1 via miR-140 and downregulation of the IL-1β-induced expression of extracellular matrix degrading enzymes such as MMP-13 and ADAMTS-5. CA: Carnosic acid; HO-1: Heme oxygenase-1; Nrf2: Nuclear factor erythroid 2-related factor 2; IL: Interleukin; MMP: Matrix metalloproteinase; ADAMTS: A disintegrin and metalloproteinase with thrombospondin motifs; miR-140: MicroRNA 140.

Citation: Ravalli S, Szychlinska MA, Leonardi RM, Musumeci G. Recently highlighted nutraceuticals for preventive management of osteoarthritis. World J Orthop 2018; 9(11): 255-261
URL: https://www.wjgnet.com/2218-5836/full/v9/i11/255.htm
DOI: https://dx.doi.org/10.5312/wjo.v9.i11.255