Systematic review on the use of autologous matrix-induced chondrogenesis for the repair of articular cartilage defects in patients

Table 3 Summary of patient outcome scores of the 16 reviewed studies

Ref.	Sub-groupings (Where Applicable)	Follow-up (mo)	Outcomes
			KOOS		IKDC		VAS		ICRS		Cincinnati		Lysholm		Other
			Pre-surgery	At follow-up	Pre-surgery	At mean follow-up	Pre-surgery	At mean follow-up	Pre-surgery	At mean follow-up	Pre-surgery	At mean follow-up	Pre-surgery	At mean follow-up	Pre-surgery	At mean follow-up
Buda et al[15]		29 ± 4.1	47.1 ± 14.9	93.3 ± 6.8	32.9 ± 14.2	90.4 ± 9.2
Gille et al[26]		48							31 ± 15	37 ± 4	46 ± 18	37 ± 9	36 ± 21	47 ± 22
Dhollander et al[16]		24	41.6	71.4			5.2	1.4
Dhollander et al[13]		24	37.6 ± 16.7	73.1 ± 25			6.1 ± 2.4	1.9 ± 3.4
Kusano et al[22]	ocF	28.8 ± 1.5			44 ± 25	88 ± 9	6 ± 3	1 ± 1					50 ± 25	94 ± 8
	cP	28.8 ± 1.5			51 ± 25	74 ± 17	6 ± 2	2 ± 2					58 ± 17	85 ± 13
	cF	28.8 ± 1.5			45 ± 26	68 ± 14	6 ± 3	3 ± 3					56 ± 25	76 ± 18
Leunig et al[23]		Not specified
Pascarella et al[24]		24			30	83							54	98
Anders et al[3]	MFx	24							54 ± 21	19 ± 17	40 ± 9	83 ± 8
	Sutured AMIC	24							46 ± 19	14 ± 13	43 ± 16	88 ± 9
	Glued AMIC	24							48 ± 20	16 ± 13	48 ± 15	85 ± 18
Gille et al[28]		24					7 ± 1.8	2 ± 2.1					50.1 ± 19.6	85.2 ± 18.4
Valderrabano et al[17]		31					5 ± 2	2 ± 2							62.2 ± 15.8 (AOFAS)	89.2 ± 12.3 (AOFAS)
Wiewiorski et al[25]		23					4.8 ± 1.6	1.3 ± 2							60.6 ± 15.5 (AOFAS)	90.9 ± 11.4 (AOFAS)
Dhollander et al[29]		24	44.5 ± 17.5	65.0 ± 23.3			73.9 ± 20.8	39.4 ± 28.8							1.5 ± 1.4 (Tegner)	2.5 ± 1.5 (Tegner)
															41.9 ± 15.1 (Kujala)	59.8 ± 21.2 (Kujala)
Mancini et al[30]		60													44.9 ± 5.9 (mHHS)	84 ± 5.9 (mHHS)
Fontana et al[31]	Defect < 4 cm2	60													44.7 (34-60) (mHHS)	Improvements demonstrated on graoh but not quantified
	Defect > 4 cm2	60													44.7 (34-60) (mHHS)
Kubosch et al[32]		39.5 ± 18.4					7.8 ± 2.1	3.2 ± 2.4								82.6 ± 3.4 (AOFAS) 33.7% ± 23.8 (FFI) 52.7 ± 15.9 (MOCART)
Shetty et al[34]		48	64.7	88.2	39	78.6							50.8	80.4

KOOS: Knee injury and Osteoarthritis Outcome Score; IKDC: International Knee Documentation Committee; VAS: Visual Analogue Scale; AOFAS: American Orthopaedic Foot and Ankle Society; ICRS: International Cartilage Repair Society; mHHS: Modified Harris Hip Score; FFI: Foot Function Index; MOCART: Magnetic resonance Observation of Cartilage Repair Tissue.