Systematic review on the use of autologous matrix-induced chondrogenesis for the repair of articular cartilage defects in patients

Table 2 Treatment algorithms

Ref.	Drilling technique	Scaffold/fixation	Associated surgery	Joint	Rehab
Buda et al[15]	No drilling	Hyalofast + PRP	3 osteotomy	Knees	NWB 4 wk, run 6 mo, RTS 12 mo
Gille et al[26]	Awl/sharp cannula	ChondroGide Fibrin glue	2 realignments, 1 capsular shift	Knees	Immobilization 1 wk, passive motion 6 wk, NWB 6 wk
Dhollander et al[16]	Microdrill	ChondroGide + PRP Sutures	3 osteotomy + 1 medial patello-femoral ligament reconstruction	Knees	NWB 2 wk, brace 0-90 for 4 wk, full ROM at 8 wk, Low impact sports 12 mo
Dhollander et al[13]	Microdrill	Chondrotissue Pin	1 osteotomy	Knees	NWB 2 wk, 0-90o 4 wk, full range 8 wk, RTS 12 mo
Kusano et al[22]	Awl	ChondroGide Suture/fibrin glue	28 osteotomy	Knees	PWB 6 wk, 0-60 4wk
Leunig et al[23]	Kirchner wire	ChondroGide, fibrin glue	3 osteoplasty, 2 femoral neck lengthening, drilling of acetabular defects	Hips	PWB 6-8 wk, passive motion 6-8 h for 6-8 wk
Pascarella et al[24]	Kirchner wire	ChondroGide Fibrin glue		Knees
Anders et al[3]	Awl	ChondroGide Suture/fibrin glue		Knees	PWB and lymphatic draining massage 3-6 wk, FWB at 4-6 mo, RTS 3-18 mo
Gille et al[28]	Awl	ChondroGide Fibrin glue	2 patella realignments, 3 corrective osteotomies, 6 partial menisectomies, 1 ACL reconstruction	Knees
Valderrabano et al[17]	Microdrill	ChondroGide Fibrin glue	16 osteotomy	Ankles	PWB, ROM of < 200 passive motion machine, lymphatic drainage massage 6wks, FWB 6-12 wk, Light sports 12 wk, RTS 5-6 mo
Wiewiorski et al[25]	Microdrill	ChondroGide Fibrin glue		Ankles (talus)	PWB and lymphatic draining massage 6 wk, FWB 12 wk
Dhollander et al[29]	Slow speed 1.2 mm diameter	ChondroGide Vicryl 6/0	No	Knees (Patellofemoral joint)	NWB for 2 wk, FWB at 10 wk, full range of motion at 8 wk, low impact sports 12 mo
Mancini et al[30]	Awl/sharp cannula	ChondroGide Fibrin glue	All patients had cam-type and/or pincer-type impingement, and underwent arthroscopic femoral head-neck resection arthroplasty and/or arthroscopic acetabular rim trimming and labral reattachment to the acetabular rim with suture anchors	Hips	PWB (30% of body weight) for 4 wk, impact sports 3 mo, complete RTS 6 mo
Fontana et al[31]	Awl/sharp cannula	ChondroGide Fibrin glue	All patients had cam-type and/or pincer-type impingement, and underwent arthroscopic femoral head-neck resection arthroplasty and/or arthroscopic acetabular rim trimming and labral reattachment to the acetabular rim with suture anchors	Hips	PWB for 7 wk, light sporting activities 4 wk, low impact sports 6 mo, complete RTS 12 mo
Kubosch et al[32]	Not specified	ChondroGide Fibrin glue	All patients also underwent autologous cancellous bone grafting to the site	Ankles (talus)	Ankle immobilisation for 2 wk, PWB for 6 wk
Shetty et al[34]	Microdrill	Tiseel Coltrix (atelocollagen)	-	Knees	PWB for 6 wk, gradual increase to FWB by next 6 wk

PRP: Platelet-rich plasma; ACL: Anterior cruciate ligament; PWB: Partial weight bearing; NWB: Non-weight bearing; FWB: Full weight bearing; ROM: Range of motion; RTS: Return to sport.