Systematic review of bone marrow stimulation for osteochondral lesion of talus - evaluation for level and quality of clinical studies

Table 2 Studies included and demographic datas

Ref.	Year	No. of ankles	No. of males	No. of females	Follow -up (mo)	Lesion area (mm2)	Lesion diameter (mm)	Prognostic factors	LOE	MCMS (points)
[23]	2013	50	20	30	35.5	61.7	8.8	Lesion size	III	58
[29]	2015	15	7	8	94.8	87		Lesion size	IV	50
[5]	2009	120	80	37	35.6	111.7	11.4	Lesion size	III	56
[3]	2013	399			74	111.3		Lesion size, contained	III	61
[32]	2015	90	68	22	38.3	100		Lesion size	III	67
[24]	2013	298	184	114	52	98.5		Lesion size	III	57
[19]	2012	173	121	52	70.3	95.4		Lesion size	III	54
[4]	2008	105	73	32	31.6		8.84	Lesion size	IV	57
[16]	2000	17	13	4	84	85.2		Lesion size	III	33
[13]	2006	10	6	4	53	450		Lesion size	III	61
[18]	2011	22	16	6	32	76		Lesion size	IV	45
[30]	2014	50	28	22	27.1			Lesion size	III	69
[20]	2012	22	12	10	24			Lesion size	IV	56
[21]	2012	81	64	17	37.4	100		Lesion size	III	89
[17]	2010	35	27	8	33	90		Lesion size	IV	50
[31]	2014	58	37	21	35	124		Lesion size	IV	65
[25]	2013	50	30	20	141		8.8	Lesion size	IV	62
[26]	2013	38	23	15	52.8	100		Lesion size	IV	52
[27]	2013	50	22	28	36.3	62		Lesion size	IV	66
[28]	2015	41	17	24	42.5	67		Lesion size	IV	56
[22]	2012	25	19	5	32	110		Lesion size	IV	48
[7]	2011	130	64	66	37.2	84		Lesion size, contained	IV	50

LOE: Level of evidence; MCMS: Modified coleman methodology score.