Risk assessment instruments for screening bone mineral density in a Mediterranean population

Table 3 Receiver operating curve analysis using Greek population values for osteoporosis risk

	Area	95%CI		Cut-off	Sensitivity	Specificity	PPV	NPV	P-value
SCORE1	0.613	0.576	0.650	20.75 >	61%	60%	46%	73%	< 0.0005
ORAI1	0.640	0.603	0.676	9.5 >	72%	52%	46%	76%	< 0.0005
				10.5 >	62%	62%	48%	74%
ABONE1	0.631	0.595	0.668	1.5 >	65%	41%	32%	85%	< 0.0005
OST1	0.643	0.607	0.678	-2.9 >	77%	46%	45%	78%	< 0.0005
BW1	0.592	0.555	0.630	70.5 <	51%	61%	42%	68%	< 0.0005
OSIRIS1	0.609	0.572	0.645	0.5 <	59%	59%	44%	71%	< 0.0005

¹High risk for osteoporosis: T-score ≤ -2. SCORE: Simple calculated osteoporosis risk estimation; ORAI: Osteoporosis risk assessment instrument; ABONE: Age, body size, no estrogen; OST: Osteoporosis self-assessment tool; BW: Body weight; OSIRIS: Osteoporosis index of risk; PPV: Positive predictive value; NPV: Negative predictive value.