Depression and psychiatric disease associated with outcomes after anterior cruciate ligament reconstruction

doi:10.5312/wjo.v7.i11.709

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Nov 18, 2016 (publication date) through Jan 2, 2025

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World Journal of Orthopedics

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2218-5836

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Orthop. Nov 18, 2016; 7(11): 709-717
Published online Nov 18, 2016. doi: 10.5312/wjo.v7.i11.709

Table 2 Systemic effects of clinical depression on immune system and hypothalamic-pituitary-adrenal axis

Target system	Effect
Immunologic system	Increased interleukin-1 Increased interleukin-6 Increased tumor necrosis factor-α
Musculoskeletal system	Decreased bone formation Increased bone resorption (likely 2/2 increased interleukin-1 and subsequent osteoclast activity)
Hypothalamic-pituitary-adrenal axis	Increased cortisol

Citation: Wu HH, Liu M, Dines JS, Kelly JD, Garcia GH. Depression and psychiatric disease associated with outcomes after anterior cruciate ligament reconstruction. World J Orthop 2016; 7(11): 709-717
URL: https://www.wjgnet.com/2218-5836/full/v7/i11/709.htm
DOI: https://dx.doi.org/10.5312/wjo.v7.i11.709