Interleukins and interleukin receptors in rheumatoid arthritis: Research, diagnostics and clinical implications

Table 2 The examined interleukin and interleukin receptor gene polymorphisms that are associated with rheumatoid arthritis

Gene	Polymorphism	Population	Ref.
IL-1B	rs16944	Algerian, British, Turkish	[34,35,40]
	rs1143623	British	[35]
	rs1143634	Algerian, Asian, Turkish	[34,40-42]
IL1-RN	rs419598	Black South Africans	[36]
IL-2/IL-21	rs907715	Australasian	[72]
	rs6822844	Australasian, Dutch	[65,72]
	rs17388568	Australasian	[72]
IL-2RA	rs2104286	Dutch	[64]
IL-4	rs2243250	Egyptian, Polish	[51,52]
IL-4R	rs1801275	African American, Egyptian	[54,55]
	rs1805010	African American, Egyptian	[54,55]
IL-6	rs1800795	Iranian, United Kingdom, Spain, Spanish, Turkish	[34,114,116, 117,122]
	rs1800796	Han Chinese, Taiwan, Turkish	[34,43,47,118]
IL-8	rs112664	Taiwan	[118]
	rs2227306	Caucasian	[137]
IL-10	rs1800871	Malaysian, Polish	[80,81]
	rs1800872	Chinese, Malaysian, Polish	[80-82]
	rs1800896	Malaysian, Polish	[80,81]
IL-15	rs2322182	North European	[59]
	rs4371699	North European	[59]
	rs6821171	North European	[59]
	rs7665842	North European	[59]
	rs7667746	North European	[59]
IL-17A	rs1974226	Japanese	[136]
	rs2275913	Norwegian	[135]
	rs3748067	Japanese	[136]
	rs3804513	Japanese	[136]
IL-17F	rs763780	Polish	[134]
	rs2397084	Polish	[134]
IL-18	rs187238	Chinese, Egyptian	[46,47]
	rs549908	Taiwan	[48]
	rs360718	Japanese	[49]
	rs360722	Japanese	[49]
	rs1946518	Chinese, Egyptian, Japanese	[46,47,49]
IL-23R	rs1004819	European, New Zealand, Spanish	[97,100,106]
	rs1343151	European, New Zealand, Spanish	[97,100,106]
	rs1495965	Spanish	[97]
	rs2201841	European, New Zealand, Hungarian	[96,97,100,106]
	rs7517847	European, New Zealand, Spanish	[97,100,106]
	rs7530511	Caucasian	[98]
	rs10889677	Hungarian	[96]
	rs11209026	European, Caucasian, New Zealand	[98,100,106]
	rs11209032	Spanish	[97]
	rs10489629	Europan, New Zealand, Spanish	[97,100,106]