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Copyright ©2014 Baishideng Publishing Group Inc.
World J Orthop. Sep 18, 2014; 5(4): 496-503
Published online Sep 18, 2014. doi: 10.5312/wjo.v5.i4.496
Table 1 Janus kinase small molecule inhibitors in development
SMIJAK Specificity/other kinase inhibitory activityRef.
SAR302503 (Fedratinib)JAK2[46]
CEP701 (Lestaurtinib)JAK2[47]
SB1518 (Pacritinib)JAK2/FLT31[48]
XL-019JAK2[48]
LY2784544JAK2/V617F2[49,50]
AZD1480JAK2[51]
NS-108JAK2/Src3[52]
BMS-911453JAK2[53]