Effect of risedronate on speed of sound in postmenopausal women with osteoporosis

Table 2 Changes in speed of sound and biochemical markers

	Baseline	3 mo	6 mo	12 mo
SOS (m/s)	1473 ± 13		1483 ± 16	1483 ± 17
Percent changes from baseline			0.68% ± 1.10%	0.65% ± 1.24%
Calcium (mg/dL)	9.2 ± 0.4		9.2 ± 0.5	9.2 ± 0.4
Percent changes from baseline			−0.43% ± 3.36%	0.30% ± 3.68%
Phosphorus (mg/dL)	3.5 ± 0.3		3.5 ± 0.6	3.5 ± 0.4
Percent changes from baseline			2.48% ± 17.6%	1.17% ± 9.85%
ALP (IU/L)	229 ± 63		187 ± 57	177 ± 48
Percent changes from baseline			−17.2% ± 16.7%	− 21.2% ± 16.7%
Urinary NTX (nmol BCE/mmol Cr)	56.2 ± 17.8	35.9 ± 11.3
Percent changes from baseline		−34.7% ± 15.0%

Data are expressed as mean ± SD. The normal ranges of serum calcium, phosphorus, and alkaline phosphatase (ALP) were 8.4-10.2 mg/dL, 2.5-4.5 mg/dL, and 100-340 IU/L, respectively. The standard range of urinary cross-linked N-terminal telopeptides of type I collagen (NTX) was 9.3-54.3 nmol bone collagen equivalent (BCE)/mmol creatinine (Cr), and the cutoff values for bone loss and vertebral fracture risk were 35.3 and 54.3 nmol BCE/mmol Cr, respectively. SOS: Speed of sound.