Molecular mechanisms of triggering, amplifying and targeting RANK signaling in osteoclasts

Figure 1 Three phases of receptor activator of nuclear factor-κB signaling during osteoclast differentiation. Osteoclast differentiation downstream of receptor activator of nuclear factor-κB (RANK) signaling is divided into triggering, amplifying and targeting phases, based on the nuclear factor of activated T-cells cytoplasmic 1 activation state. ITAM: Immunoreceptor tyrosine-based activation motif; TRAF6: Tumor necrosis factor receptor-associated factor 6; Gab2: Grb-2-associated binder-2; PLCγ2: Phospholipase C γ2; RANKL: RANK ligand; Ig: Immunoglobulin.