Role of neurogenic inflammation in intervertebral disc degeneration

Figure 2 The relationship between severe disc degeneration and Modic changes in the endplates. A: Lateral radiograph of the lumbar spine showed significant narrowing of the L4/5 intervertebral space, osteophyte formation at the edges of the vertebral bodies, and sclerosis of the upper and lower endplates; B and C: T2-weighted and T1-weighted magnetic resonance imaging revealed bone marrow hypersignal in the upper and lower endplates of the L4/5 disc, respectively, indicating Modic changes type 2 in the vertebral endplates (bone marrow fatty degeneration).