Systematic Reviews
Copyright ©The Author(s) 2024.
World J Orthop. Mar 18, 2024; 15(3): 266-284
Published online Mar 18, 2024. doi: 10.5312/wjo.v15.i3.266
Table 1 Characteristics of included studies in the network meta-analysis, each row depicts the individual comparator arm in the studies included
Ref.
Country
Study design
Sample size
Treatment
Mean age
Female
Mean defect size
Follow-up (months)
Control
Intervention
Control
Intervention
Control
Intervention
Control
Intervention
Control
Intervention
Volz et al[31], 2017GermanyRCT3413AMICMicrofracture40.036.5733.92.960
Niemeyer et al[32], 2019GermanyRCT5250MACIMicrofracture36.037.019222.72.424
Fossum et al[33], 2019NorwayRCT2120ACI-CAMIC37.238.37124.95.224
Ulstein et al[34], 2014NorwayRCT1114MicrofractureAOT31.732.71192.63.0120
Visna et al[35], 2004Czech RepublicRCT2525Autologous chondrograft transplantationMicrofracture29.432.27943.312
Assche et al[36], 2010BelgiumRCT3334ACI-PMicrofracture34.034.011102.52.324
Saw et al[37], 2013United StatesRCT2425Microfracture with HAMicrofracture with PBSC42.038.01715NANA18
Anders et al[38], 2013GermanyRCT228AMICMicrofracture41.038.017153.73.524
Lee et al[15], 2013Republic of KoreaRCT2524MicrofractureMicrofracture with PRP46.046.010103.03.024
Brittberg et al[39], 2018SwedenRCT6563MACIMicrofracture38.034.023205.14.960
Lim et al[40], 2012South KoreaRCT3022MicrofractureAOT32.930.412102.72.760
18ACI-P25.182.860
Knutsen et al[41], 2007NorwayRCT4040ACI-PMicrofracture33.331.15.05.060
Knutsen et al[42], 2016NorwayRCT4040ACI-PMicrofracture33.331.15.05.0180
Liu et al[43], 2021TaiwanRCT105KartigenMicrofracture54.867.8532.91.024
Yoon et al[44], 2020Republic of KoreaRCT2010ACI-CCPMicrofracture41.547.2673.52.512
Kon et al[45], 2018ItalyRCT5149Collagen HAMicrofracture34.035.215183.43.424
Vanlauwe et al[46], 2011BelgiumRCT5161ACI-PMicrofracture33.933.922202.62.460
Stanish et al[20], 2013CanadaRCT4139Microfracture with BST-CarGelMicrofracture35.137.21814NANA12
Basad et al[47], 2010GermanyRCT4020MACIMicrofracture33.037.51537.07.024
Solheim et al[48], 2018NorwayRCT2020MicrofractureMosaicplasty35.031.0664.04.0180
Bisicchia et al[49], 2020ItalyRCT2020Microfracture with SVFMicrofracture49.846.1873.23.112
Saris et al[50], 2014NetherlandsRCT7272MACIMicrofracture34.832.927244.94.724
Saris et al[51], 2008NetherlandsRCT5761ACI-PMicrofracture33.933.922202.62.412
Saris et al[9], 2009NetherlandsRCT5761ACI-PMicrofracture33.933.922202.62.436
Qiao et al[52], 2020ChinaRCT1010MicrofractureMicrofracture with HA62.359.7754.04.012
10Microfracture with MSC62.074.012
Nguyen et al[53], 2017VietnamRCT1515Microfracture with SVFMicrofracture58.658.21212NANA18
Lim et al[54], 2021Republic of KoreaRCT4346Microfracture with MSCMicrofracture55.354.428304.94.060
Venosa et al[55], 2022ItalyRCT1919Microfracture with PRPMicrofracture with MSC56.455.87101.01.012
Shive et al[19], 2015CanadaRCT3426Microfracture with BST-CarGelMicrofracture34.340.112122.42.060
Koh et al[13], 2016Republic of KoreaRCT4040Microfracture with MSCMicrofracture39.138.424264.84.624
Knutsen et al[4], 2004NorwayRCT4040ACI-PMicrofracture33.031.116165.14.524
Kim et al[56], 2017South KoreaRCT1414MicrofractureMicrofracture with Collagen55.755.4012.93.612
Kim et al[57], 2020South KoreaRCT4852MicrofractureMicrofracture with Collagen51.748.99124.63.924
Kane et al[58], 2018United StatesRCT219NeocartMicrofracture41.438.8232.21.760
Ibarra et al[59], 2021United StatesRCT2424MACIMicrofracture33.735.87101.91.772
Hashimoto et al[60], 2019JapanRCT74Microfracture with MSCMicrofracture42.646.3403.04.412
Gudas et al[61], 2006LithuaniaRCT2829AOTMicrofracture24.624.310122.82.736
Gudas et al[62], 2013LithuaniaRCT2829AOTMicrofracture24.624.310122.72.8120
Gudas et al[63], 2005LithuaniaRCT2928MicrofractureAOT24.324.612102.82.736
Glasbrenner et al[64], 2020GermanyRCT1212MicrofractureMicrofracture with BMAC36.747.9361.71.712
Dasar et al[65], 2016TurkeyRCT2020MicrofractureCarbon fibre rod36.438.515153.54.0.24
Crawford et al[66], 2012United StatesRCT219NeoCartMicrofracture41.039.0232.82.524
Cole et al[67], 2011United StatesRCT920MicrofractureMACI33.032.7463.42.724
Chung et al[68], 2014South KoreaRCT2412Microfracture with BMACMicrofracture47.444.310101.31.524