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©The Author(s) 2024.
World J Orthop. Mar 18, 2024; 15(3): 266-284
Published online Mar 18, 2024. doi: 10.5312/wjo.v15.i3.266
Published online Mar 18, 2024. doi: 10.5312/wjo.v15.i3.266
Ref. | Country | Study design | Sample size | Treatment | Mean age | Female | Mean defect size | Follow-up (months) | |||||
Control | Intervention | Control | Intervention | Control | Intervention | Control | Intervention | Control | Intervention | ||||
Volz et al[31], 2017 | Germany | RCT | 34 | 13 | AMIC | Microfracture | 40.0 | 36.5 | 7 | 3 | 3.9 | 2.9 | 60 |
Niemeyer et al[32], 2019 | Germany | RCT | 52 | 50 | MACI | Microfracture | 36.0 | 37.0 | 19 | 22 | 2.7 | 2.4 | 24 |
Fossum et al[33], 2019 | Norway | RCT | 21 | 20 | ACI-C | AMIC | 37.2 | 38.3 | 7 | 12 | 4.9 | 5.2 | 24 |
Ulstein et al[34], 2014 | Norway | RCT | 11 | 14 | Microfracture | AOT | 31.7 | 32.7 | 11 | 9 | 2.6 | 3.0 | 120 |
Visna et al[35], 2004 | Czech Republic | RCT | 25 | 25 | Autologous chondrograft transplantation | Microfracture | 29.4 | 32.2 | 7 | 9 | 4 | 3.3 | 12 |
Assche et al[36], 2010 | Belgium | RCT | 33 | 34 | ACI-P | Microfracture | 34.0 | 34.0 | 11 | 10 | 2.5 | 2.3 | 24 |
Saw et al[37], 2013 | United States | RCT | 24 | 25 | Microfracture with HA | Microfracture with PBSC | 42.0 | 38.0 | 17 | 15 | NA | NA | 18 |
Anders et al[38], 2013 | Germany | RCT | 22 | 8 | AMIC | Microfracture | 41.0 | 38.0 | 17 | 15 | 3.7 | 3.5 | 24 |
Lee et al[15], 2013 | Republic of Korea | RCT | 25 | 24 | Microfracture | Microfracture with PRP | 46.0 | 46.0 | 10 | 10 | 3.0 | 3.0 | 24 |
Brittberg et al[39], 2018 | Sweden | RCT | 65 | 63 | MACI | Microfracture | 38.0 | 34.0 | 23 | 20 | 5.1 | 4.9 | 60 |
Lim et al[40], 2012 | South Korea | RCT | 30 | 22 | Microfracture | AOT | 32.9 | 30.4 | 12 | 10 | 2.7 | 2.7 | 60 |
18 | ACI-P | 25.1 | 8 | 2.8 | 60 | ||||||||
Knutsen et al[41], 2007 | Norway | RCT | 40 | 40 | ACI-P | Microfracture | 33.3 | 31.1 | 5.0 | 5.0 | 60 | ||
Knutsen et al[42], 2016 | Norway | RCT | 40 | 40 | ACI-P | Microfracture | 33.3 | 31.1 | 5.0 | 5.0 | 180 | ||
Liu et al[43], 2021 | Taiwan | RCT | 10 | 5 | Kartigen | Microfracture | 54.8 | 67.8 | 5 | 3 | 2.9 | 1.0 | 24 |
Yoon et al[44], 2020 | Republic of Korea | RCT | 20 | 10 | ACI-CCP | Microfracture | 41.5 | 47.2 | 6 | 7 | 3.5 | 2.5 | 12 |
Kon et al[45], 2018 | Italy | RCT | 51 | 49 | Collagen HA | Microfracture | 34.0 | 35.2 | 15 | 18 | 3.4 | 3.4 | 24 |
Vanlauwe et al[46], 2011 | Belgium | RCT | 51 | 61 | ACI-P | Microfracture | 33.9 | 33.9 | 22 | 20 | 2.6 | 2.4 | 60 |
Stanish et al[20], 2013 | Canada | RCT | 41 | 39 | Microfracture with BST-CarGel | Microfracture | 35.1 | 37.2 | 18 | 14 | NA | NA | 12 |
Basad et al[47], 2010 | Germany | RCT | 40 | 20 | MACI | Microfracture | 33.0 | 37.5 | 15 | 3 | 7.0 | 7.0 | 24 |
Solheim et al[48], 2018 | Norway | RCT | 20 | 20 | Microfracture | Mosaicplasty | 35.0 | 31.0 | 6 | 6 | 4.0 | 4.0 | 180 |
Bisicchia et al[49], 2020 | Italy | RCT | 20 | 20 | Microfracture with SVF | Microfracture | 49.8 | 46.1 | 8 | 7 | 3.2 | 3.1 | 12 |
Saris et al[50], 2014 | Netherlands | RCT | 72 | 72 | MACI | Microfracture | 34.8 | 32.9 | 27 | 24 | 4.9 | 4.7 | 24 |
Saris et al[51], 2008 | Netherlands | RCT | 57 | 61 | ACI-P | Microfracture | 33.9 | 33.9 | 22 | 20 | 2.6 | 2.4 | 12 |
Saris et al[9], 2009 | Netherlands | RCT | 57 | 61 | ACI-P | Microfracture | 33.9 | 33.9 | 22 | 20 | 2.6 | 2.4 | 36 |
Qiao et al[52], 2020 | China | RCT | 10 | 10 | Microfracture | Microfracture with HA | 62.3 | 59.7 | 7 | 5 | 4.0 | 4.0 | 12 |
10 | Microfracture with MSC | 62.0 | 7 | 4.0 | 12 | ||||||||
Nguyen et al[53], 2017 | Vietnam | RCT | 15 | 15 | Microfracture with SVF | Microfracture | 58.6 | 58.2 | 12 | 12 | NA | NA | 18 |
Lim et al[54], 2021 | Republic of Korea | RCT | 43 | 46 | Microfracture with MSC | Microfracture | 55.3 | 54.4 | 28 | 30 | 4.9 | 4.0 | 60 |
Venosa et al[55], 2022 | Italy | RCT | 19 | 19 | Microfracture with PRP | Microfracture with MSC | 56.4 | 55.8 | 7 | 10 | 1.0 | 1.0 | 12 |
Shive et al[19], 2015 | Canada | RCT | 34 | 26 | Microfracture with BST-CarGel | Microfracture | 34.3 | 40.1 | 12 | 12 | 2.4 | 2.0 | 60 |
Koh et al[13], 2016 | Republic of Korea | RCT | 40 | 40 | Microfracture with MSC | Microfracture | 39.1 | 38.4 | 24 | 26 | 4.8 | 4.6 | 24 |
Knutsen et al[4], 2004 | Norway | RCT | 40 | 40 | ACI-P | Microfracture | 33.0 | 31.1 | 16 | 16 | 5.1 | 4.5 | 24 |
Kim et al[56], 2017 | South Korea | RCT | 14 | 14 | Microfracture | Microfracture with Collagen | 55.7 | 55.4 | 0 | 1 | 2.9 | 3.6 | 12 |
Kim et al[57], 2020 | South Korea | RCT | 48 | 52 | Microfracture | Microfracture with Collagen | 51.7 | 48.9 | 9 | 12 | 4.6 | 3.9 | 24 |
Kane et al[58], 2018 | United States | RCT | 21 | 9 | Neocart | Microfracture | 41.4 | 38.8 | 2 | 3 | 2.2 | 1.7 | 60 |
Ibarra et al[59], 2021 | United States | RCT | 24 | 24 | MACI | Microfracture | 33.7 | 35.8 | 7 | 10 | 1.9 | 1.7 | 72 |
Hashimoto et al[60], 2019 | Japan | RCT | 7 | 4 | Microfracture with MSC | Microfracture | 42.6 | 46.3 | 4 | 0 | 3.0 | 4.4 | 12 |
Gudas et al[61], 2006 | Lithuania | RCT | 28 | 29 | AOT | Microfracture | 24.6 | 24.3 | 10 | 12 | 2.8 | 2.7 | 36 |
Gudas et al[62], 2013 | Lithuania | RCT | 28 | 29 | AOT | Microfracture | 24.6 | 24.3 | 10 | 12 | 2.7 | 2.8 | 120 |
Gudas et al[63], 2005 | Lithuania | RCT | 29 | 28 | Microfracture | AOT | 24.3 | 24.6 | 12 | 10 | 2.8 | 2.7 | 36 |
Glasbrenner et al[64], 2020 | Germany | RCT | 12 | 12 | Microfracture | Microfracture with BMAC | 36.7 | 47.9 | 3 | 6 | 1.7 | 1.7 | 12 |
Dasar et al[65], 2016 | Turkey | RCT | 20 | 20 | Microfracture | Carbon fibre rod | 36.4 | 38.5 | 15 | 15 | 3.5 | 4.0. | 24 |
Crawford et al[66], 2012 | United States | RCT | 21 | 9 | NeoCart | Microfracture | 41.0 | 39.0 | 2 | 3 | 2.8 | 2.5 | 24 |
Cole et al[67], 2011 | United States | RCT | 9 | 20 | Microfracture | MACI | 33.0 | 32.7 | 4 | 6 | 3.4 | 2.7 | 24 |
Chung et al[68], 2014 | South Korea | RCT | 24 | 12 | Microfracture with BMAC | Microfracture | 47.4 | 44.3 | 10 | 10 | 1.3 | 1.5 | 24 |
- Citation: Muthu S, Viswanathan VK, Sakthivel M, Thabrez M. Does progress in microfracture techniques necessarily translate into clinical effectiveness? World J Orthop 2024; 15(3): 266-284
- URL: https://www.wjgnet.com/2218-5836/full/v15/i3/266.htm
- DOI: https://dx.doi.org/10.5312/wjo.v15.i3.266