Impacts of mesenchymal stem cells and hyaluronic acid on inflammatory indicators and antioxidant defense in experimental ankle osteoarthritis

Figure 4 Effect of bone marrow mesenchymal stem cells and/ or hyaluronic acid treatments. A: Effect of bone marrow mesenchymal stem cells (BMMSCs) and/or hyaluronic acid (HA) treatments on serum lipid peroxidation (LPO) level of monosodium iodate-administered rats; B: Effect of BMMSC and/or HA treatments on serum glutathione S-transferase (GST) activity in monosodium iodate-administered rats; C: Effect of BMMSC and/or HA treatments on serum glutathione (GSH) content in monosodium iodate-administered rats; D: Effect of BMMSC and/or HA treatments on matrix metalloproteinase 13 (MMP-13) mRNA expression level in joint tissue of monosodium iodate-administered rat; E: Effect of BMMSCs and/or HA treatments on transforming growth factor-β (TGF-b) protein expression level in the joint tissue of monosodium iodate-administered rat; F: Effect of BMMSCs and/or HA treatments on the histopathological arthritis score monosodium iodate-administered rat. The histological lesion scores of synovitis (synovial inflammation), pannus formation, bone resorption, and cartilage destruction were demonstrated. ^aP < 0.05, compared values with b, c and d are significantly different; ^bP < 0.05, compared values with a, c and d are significantly different; ^cP < 0.05, compared values with a, b and d are significantly different; ^dP < 0.05, compared values with a, b, and c are significantly different.